An estimated 8-12 million people in the US are diagnosed with Peripheral Arterial Disease (PAD), which is the leading cause of limb amputation in adults. Patients suffering with PAD can experience claudication, potential amputations, and higher than expected rates of heart attack and stroke. Fortunately, through technological and medical advances, there is hope for an effective treatment that will potentially save the quality of life for many patients. This treatment can regulate macrophage polarization to promote angiogenesis and arteriogenesis to revascularize ischemic muscle, but cell-specific-function, downstream mechanisms, and signaling is unclear. With the discovery of this novel approach to treating PAD, scientists and researchers everywhere could benefit from a visual representation, as it is currently not well understood. This project consists of a 3D animation explaining what PAD is and depicting the mechanism of action for this type of treatment: An intramuscular injection that will ignite a propagation of repair within the tissue, taking advantage of the body’s own healing properties. 3D animation was chosen for this project because of its positive effect in education among professionals and the public and because of its ability to be utilized in presentations.
Potential Contribution to Biocommunication
Based on conclusions from an existing literature and media review, few 3D animations exist that explain PAD, and there is little to no visual representation of the specific repair mechanism that will be covered in this project. Additionally, this project can potentially influence a greater use of 3D visuals to explain different mechanisms of action in an educational setting
Faculty advisors: Michael Jensen (primary) and Amanda Behr (secondary)
Medical Illustration, Augusta University
Content expert: Brian Annex, M.D.
Department of Vascular Biology, Medical College of Georgia
Animation available upon request